amyotrophic lateral sclerosis

noun

amyo·​tro·​phic lateral sclerosis ˌā-ˌmī-ə-ˈtrō-fik- How to pronounce amyotrophic lateral sclerosis (audio) -ˈträ- How to pronounce amyotrophic lateral sclerosis (audio)
: a rare progressive degenerative fatal disease affecting the motor neurons, usually beginning in middle age, and characterized especially by increasing and spreading muscular weakness and atrophy
abbreviation ALS

called also Lou Gehrig's disease

Examples of amyotrophic lateral sclerosis in a Sentence

Recent Examples on the Web Sarah Seib, 39, whose husband, Jason Markle, died in 2022 of amyotrophic lateral sclerosis, commonly known as A.L.S. or Lou Gehrig’s disease, had a steady job with a local technology company. Caitlin Kelly, New York Times, 27 Apr. 2024 Doctoroff’s father died of amyotrophic lateral sclerosis (ALS) in 2004; his uncle died of the progressive nervous system disease in 2010. Dan Doctoroff, TIME, 2 May 2024 See all Example Sentences for amyotrophic lateral sclerosis 

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'amyotrophic lateral sclerosis.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

a- entry 2 + my- + -trophic

First Known Use

1875, in the meaning defined above

Time Traveler
The first known use of amyotrophic lateral sclerosis was in 1875

Dictionary Entries Near amyotrophic lateral sclerosis

amyotonia

amyotrophic lateral sclerosis

Amyraldism

Cite this Entry

“Amyotrophic lateral sclerosis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/amyotrophic%20lateral%20sclerosis. Accessed 29 May. 2024.

Medical Definition

amyotrophic lateral sclerosis

noun
: a rare fatal progressive degenerative disease that affects pyramidal motor neurons, usually begins in middle age, and is characterized especially by increasing and spreading muscular weakness
abbreviation ALS

called also Lou Gehrig's disease

More from Merriam-Webster on amyotrophic lateral sclerosis

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!